Gastro-oesophageal reflux: an overview of the pharmacotherapeutic treatment options

  • L Malan Sefako Makgatho Health Sciences University
  • Q Labuschagne Sefako Makgatho Health Sciences University
  • N Schellack Sefako Makgatho Health Sciences University
  • G Schellack
  • J C Meyer Sefako Makgatho Health Sciences University
Keywords: GORD, gastro-oesophageal reflux, PPIs, proton-pump inhibitors

Abstract

Gastro-oesophageal reflux disease (GORD) produces symptoms that cause great irritation to the patient. Pharmacotherapeutic management is directed at minimising these symptoms and reducing the causative factors, e.g. acid production, thereby providing relief. Currently available agents include simple antacids and acid suppression therapy, including histamine 2-receptor antagonists, proton pump inhibitors, mucosal or cytoprotective agents and pro-motility agents. Deciding on appropriate therapy will depend on the diagnosis, side-effects and cost-effectiveness of the treatment.

Author Biographies

L Malan, Sefako Makgatho Health Sciences University
BPharm, MScMed (Clinical pharmacy) Sefako Makgatho Health Sciences University
Q Labuschagne, Sefako Makgatho Health Sciences University
BPharm, MPharm (Clinical pharmacy) Sefako Makgatho Health Sciences University
N Schellack, Sefako Makgatho Health Sciences University
BCur, BPharm, PhD (Pharmacy) Sefako Makgatho Health Sciences University
G Schellack
BCur, Adv Univ Dipl Nurs Sc (HSM), Hons BSc (Pharmacology) Pharmaceutical Industry (Clinical Research)
J C Meyer, Sefako Makgatho Health Sciences University
BPharm, MSc (Med) Pharmacy, PhD (Pharmacy) Sefako Makgatho Health Sciences University
Section
Review Articles