Isgemiese Hartsiekte onder stedelike swartes

Abstract

As Ischaemic Heart Disease (IHD) is emerging in the South African urban block population, 30 blacks from Kalafong Hospital with proven myocardial infraction were examined to determine if there is any relationship with recognised risk factors. The diagnosis of IHD (WHO criteria) was confirmed by one or more of the following: coronary arteringraphy, radionuclide scintigraphy 201 Thallium and 99m Tc- PYP [MUGA] stress testing ) and/or necropsy. The degree of coronary artery involvement is discussed in relation to clinico- patholagic finding as well as risk factors. The Kruskal-Wallice test was used to compare the influence of the follouting uariabLes in 4 groups of patients: age, obesity, smoking, systolic and diastolic blood pressure, fasting serum glucose, cholesterol, triglycerides, HDL-cholesterol levels and cholesterol/HDL cholesterol ratio. The groups with normal coronary arteries were omitted due to lack of data. Statistically significant differences at the 0,05 level were shown, with regard to age and systolic pressure. A multiple comparison procedure according to Dunn was used to detect the origin of these overall differences. Patients with triple vessel disease were significantly older than the other groups, and their systolic blood pressure w&s higher than those with ischaemic myopathy and multiple vessel disease. All patients presented with at least 3 of the major risk factors, and there was a negative correlation between the severity of IHD and HDL-cholesterol levels. The disease manifested through a broad spectrum, i.e. single to triple vessel disease as well as coronary arteries. Luminal diameter reduction varied from 0 to 60 to 100%.