The bacterial profile and antibiotic resistance in acute uncomplicated urinary tract infection of females

Abstract

Objective: To determine the bacterial profile and antibiotic resistance in acute uncomplicated urinary tract infection (UTI) of females presenting in a family practice. Setting: A solo family practice near the Cape Town city center. Design: Prospective descriptive study. Metbods: Urine samples front all consecutive female cases of clinically suspected UTI witb microscopic bacte4uria were examined witb bacterial cultures and antibiotic sensitiuity testing to amoxycillin, cotriruoxazole, nitrofuratoin, nalidixic acid, amoxycillin/clavulanic acid, norloxacin and cefactor. Results: Of the 49 positiue cultures (growtbs > 10O 00O per ml), 37 (76%, 95%CI 64% to 88% were due to Escberica (E.) coli and 10 (20%, 95% CI 9% to 31% Stapbylococcus (S.) saprophyticus. Twenty one (56.8%, 95% CI 39.5% to 72.8%) E.coli cultures were resistant to amoxycillin, while 18 (48.6%. 95% CI 31.9% to 65.6%) were resistant to cotrimoxazole. A 100% (95% CI 69% to 100%) of S.sapropbyticus cultures were resistant to nalidixic acid. Conclusions: E.coli is tbe most preualent organism cultured in acute uncomplicated UTI of females in tbis family practice setting. Amoxycillin, cotrimoxazoie and nalidixic acid is not appropriate first line therapy due to antibiotic resistance.