Velocardiofacial syndrome case report: Is this a homogeneous genetic subtype of Schizophrenia?

Abstract

In this case report of a 29 year old Afrikaner male, a diagnosis of velocardiofacial syndrome was made on clinical grounds. Later a FISH analysis test for 22q 11 microdeletion confirmed this clinical diagnosis. Specifically two independent studies have reported that 25-31% of patients with the 22q 11 microdeletion met diagnostic criteria for the schizophrenia or schizo-affective disorders, while the microdeletion occurs in the population at a rate of 0.025% it has been found in 2% of adult schizophrenia patients in the 6% of cases with childhood onset schizophrenia.