The treatment of cholesterol: issues, effects and targets

  • James A Ker University of Pretoria
Keywords: cholesterol, statins

Abstract

Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. The end result is a significant reduction in cholesterol levels, and a consequent significant reduction in mortality and cardiovascular events in the appropriate individual.

Author Biography

James A Ker, University of Pretoria
MBChB, MMed(Int), MD Deputy Dean Senior Specialist Department of Internal Medicine Faculty of Health Sciences University of Pretoria
Issue
Vol 52, No 6 - November/December 2010
Section
Review Articles
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